Autophagy Therapy

 Autophagy is when cancer cells  undergo programmed cell death (apoptosis).

There is only one cure that I know, that uses autophagy, and that is THC.  Thus, THC activates a series of events within cancer cells, inhibiting tumour growth.

 By binding to certain cell-surface receptors, THC activates a cell signalling pathway that leads to cell death. Cannabinoid action induces autophagy-mediated cell death. A new study by Salazar et al. in The Journal of Clinical Investigation demonstrates that Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy. 

Our data indicate that THC induced ceramide accumulation and eukaryotic translation initiation factor 2α (eIF2α) phosphorylation and thereby activated an ER stress response that promoted autophagy via tribbles homolog 3–dependent (TRB3-dependent) inhibition of the Akt/mammalian target of rapamycin complex 1 (mTORC1) axis. 

We also showed that autophagy is upstream of apoptosis in cannabinoid-induced human cancer cell death and that activation of this pathway was necessary for the antitumour action of cannabinoids in vivo. These findings describe a mechanism by which THC can promote the autophagic death of human cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers.